C−H Activation Based Functionalization of Furfural Derivatives

Furfural and related compounds are building blocks of industrial interest, obtained from raw biomass. Their use as precursors basic fine chemicals has gained increasing attention a green alternative to petroleum-derived compounds. Several works have reported the functionalization furfurals obtain wider range chemicals, opening up new synthetic possibilities applications, ranging biofuels pharmaceuticals. Among these works, processes based on C−H activation most attractive ones for their atom economy possibility non-activated substrates. This minireview summarizes methods direct without prior modification redox state aldehyde function. In particular, transition metal catalyzed each bond heteroaromatic nucleus molecules is systematically discussed, well examples transformations